Hendra virus

Biocontainment

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CSIRO scientists who undertake research with Hendra virus must work at Biosafety Level 4 (BSL4) – the highest biosecurity level. This requires scientists to wear fully encapsulated suits with their own air supply.

CSIRO PhD student studying fluorescently stained images of Hendra virus infected cells on a microscope.AAHL provides a unique resource for Australia and its capacity to work with deadly BSL4 disease agents is arguably the best in the world. AAHL is the only BSL4 laboratory in Australia that focuses on researching new and emerging exotic animal diseases.

Watch the ABC Catalyst episode on Hendra virus [external link].

References

1. McEacherna JA, Bingham J, Crameri G, Green DJ, Hancock TJ, Middleton D, Feng Y-R, Broder CC, Wang L-F, Bossart KN. 2008. A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats [external link]. Vaccine. 26(31): 3842-52.

2. Bossart KN, Zhu Z, Middleton D, Klippel J, Crameri G, Bingham J, McEachern JA, Green D, Hancock TJ, Chan Y-P, Hickey AC, Dimitrov DS, Wang L-F, Broder CC. 2009. A neutralizing Human Monoclonal Antibody Protects against Lethal Disease in a New Ferret Model of Acute Nipah Virus Infection [external link]. PLoS Pathog 5(10): e1000642. doi:10.1371/journal.ppat.1000642.